Endocrine Abstracts

Objective: To describe body-composition, lipid profile, and health-related quality of life (HRQL) in patients with traumatic brain injury (TBI) in relation to the development of posttraumatic hypopituitarism.Design: Cross-sectional with a nested prospective sub-study.Patients: The cross-sectional cohort included 104 hospitalized patients with TBI (26F/78M; age: median 41 years (range 18–64); BMI: 25 kg/m2 (17–3...

Purpose: Thyrotoxic patients have an increased bone turnover and decreased Bone Mineral Density (BMD) at diagnosis. During antithyroid drug treatment (ATD) the patients improved their BMD but earlier studies have not been able to determine if BMD normalize or how long it will take.Methods: We have prospectively examined 32 females (approved by Danish Ethical Committee) with newly diagnosed Graves’ disease (antilog10, mean age (CI 95%)): 39 years (34...

Introduction: Thyroid autoimmunity has been associated with pregnancy loss. A possible mechanism is an overactive maternal immune system leading to rejection of the fetal allograft. In women with recurrent pregnancy losses (RPL), we investigated the association of thyroid peroxidase antibodies (TPOAbs) with number of losses and outcome of first pregnancy after referral.Methods: Prospective study of women with RPL (≥3) followed at the RPL Unit, Cope...

Objective: Thyroid diseases have been shown to affect quality of life. A thyroid-specific patient-reported outcome (PRO) measuring quality of life, the ThyPRO, has recently been developed and validated using classical clinic- and psycho-metric methods. The purpose of the present study was to apply modern psychometrics to validate the measure as the extent of differential item functioning (DIF) according to sex, age, education and diagnosis, within the ThyPRO.<p class="abst...

Objective: During the development of a thyroid-specific quality of life (QoL) questionnaire, patients and clinicians rated the relative relevance of a list of possibly relevant QoL issues. In this study we compare the patient and clinician ratings.Methods: Fifteen thyroid experts and 80 thyroid outpatients (14 with non-toxic goitre, 12 nodular toxic goitre, 21 Graves’ disease, 17 thyroid associated ophthalmopathy (TAO) and 16 primary hypothyroidism)...

Background and aim: In clinical populations, generic quality of life (QoL) questionnaires should be supplemented with disease-specific questionnaires, which may have higher sensitivity and clinical relevance. For the purpose of developing a comprehensive thyroid QoL questionnaire, we have evaluated the relative importance of various QoL aspects to thyroid patients.Methods: A list of problems (issues) related to thyroid diseases, previously identified thr...

Background: Scintigrafically cold nodules are hypofunctioning areas in the thyroid gland. These nodules are common and as the risk of malignancy is low, surgery is only necessary in very few cases. Fine Needle Aspiration Cytology (FNAC) is the standard method for detecting malignant tumours. However, FNAC is a difficult diagnostic procedure which often gives insufficient working material.Materials and methods: A prospective study was designed to calculat...

Objectives: Iodine intake affects the risk of thyroid disorders. This study aimed to calculate the overall incidence of thyroid dysfunctions and structural abnormalities in the Faroe Islands and to describe the relation to sex and age.Methods: We performed a nationwide, register-based study covering all 54,000 inhabitants of the Faroe Islands between 2006 and 2018. Cases were identified and classified by thyroid dysfunction using redeemed prescriptions o...

Background: Patients on long-term glucocorticoid treatment are at risk of adrenal insufficiency during glucocorticoid treatment. The side effect can occur during glucocorticoid treatment if there is a mismatch between glucocorticoid requirements and production/intake. High-dose glucocorticoid treatment is often sufficient to overcome most stressful situations. A low-dose of 5 mg prednisolone/day is however, equivalent to 20 mg hydrocortisone, a dose often used as basal glucoco...

Objective: We aimed to assess the prevalence of glucocorticoid-induced adrenal insufficiency in prednisolone treated patients, and its relation to glucocorticoid dose and duration of treatment.Subjects and measures: As part of a larger study 48 patients with rheumatoid arthritis (33 women, aged 34–85 years) treated with a mean prednisolone dose of 7.0 mg (range 5–20 mg) per day, and a mean duration of treatment of 95 months (range: 6–360 m...